Chronic endometritis
Conditions
Interventions
Endometrial tissue will be obtained by aspiration from these patients on the day of endometrial biopsy in day 15-25 of menstrual cycle. Samples of these patients will ill be used for the non-invasive
Sponsors
Kamiya Ladies Clinic
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1, The patients who has IVF-ET therapy 2, The duration of infertility over 3 years 3,Infertile women with history of recurrent implantation failure, defined as three or more failed ETs, undergoing one or more IVF cycle(s).t 4, Infertile women with history of recurrent pregnancy loss, defined as two ore more 5, Infertile women with history of recurrent chemical pregnancy, defined as two ore more 6,The patients suspected CE by hysteroscope 7,The patients who detected CD138 positive plasma cells in historical tissues 8, The patients who had bacterial vaginosis 9,BMI: 18.5 - 30 kg / m2 (both inclusive) 10,HIV, HBV, HCV, RPR negative
Exclusion criteria
Exclusion criteria: 1, The patients who has endometrial polyp, submucosal myopia, Asherman syndrome, scar of C/S in uterus. 2,Any social, medical, or psychiatric condition 3, The couple or their parents who has chromosomal aberration or carrier of translocation 4, The patients with untreated hydrosalpinx 5, Known allergy to any component of antibiotic therapy 6,,Vaginal or systemic antibiotic therapy within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The clinical pregnancy rate of the patients whose results are abnormal in EMMA/ALICE and after that who have treated with probiotics therapy | — |
Countries
Japan
Contacts
Public ContactNanako Iwami
Kamiya Ladies Clinic Reproductive Center
Outcome results
None listed