Periodontitis
Conditions
Interventions
Periocline ointment is administrated at test site after supra and subgingival scaling. Administration is repeated 3 times with 1-week interval.
Placebo ointment is administrated at test site after s
Sponsors
Niigata University
State University of New York at Buffalo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) good general health without any remarkable past history except well controlled hypertension, dyslipidemia, and diabetes 2) presence of at least 14 remaining teeth 3) history of chronic or aggressive periodontitis 4) presence of at least 2 teeth with probing pocket depth greater than or equal to 5 mm with concomitant bleeding on probing
Exclusion criteria
Exclusion criteria: 1) use of systemic or local antimicrobials in the past 6 months 2) scaling and root planing treatment under local anesthesia for target teeth in the previous 3 months 3) subgingival mechanical debridement for target teeth in the previous 1 month 4) allergies to conventional tetracycline agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences of subgingival microbiota of test group and control group between before and after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change in the counts of total and red complex bacteria of subgingival plaque of test group and control group between before and after treatment 2) Change in the clinical parameters of before and after treatment between test group and control group | — |
Countries
Japan
Contacts
Public ContactKazuhisa Yamazaki
Niigata University Graduate School of Medical and Dental Sciences Division of Oral Science for Health Promotion
Outcome results
None listed