Dry Eye Syndrome
Conditions
Interventions
Group 1 received cyclosporine 0.05% eye drops twice daily for 12 weeks
Group 2 received cyclosporine 0.09% eye drops twice daily for 12 weeks.
Sponsors
Laser Eye Clinic Noida
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects experiencing dry eye symptoms.
Exclusion criteria
Exclusion criteria: Patients with current ocular infection, history of laser in situ keratomileusis, allergic conjunctivitis, herpetic eye disease, diabetes, and liver diseases were excluded. Other exclusion criteria were pregnant or lactating mothers, HIV, and hepatitis B and C. Patients who were allergic to fluorescein were excluded. Systemic (tetracyclines and corticosteroids) or topical medications (other than artificial tear supplements) that could affect tear production or meibomian gland functions were discontinued before intervention. However, patients were instructed not to use artificial tear preparations, 2 hours before testing. Computer work was not allowed during the course of the study as concurrent use of visual display terminals may independently influence ocular surface changes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in subjective dry eye symptoms score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in the Schirmer-1 test values as a measure of tear production, TBUT as a measure of tear film stability, and CIC scores (Nelson grade) for cellular morphology and Goblet cell density. | — |
Countries
Asia(except Japan)
Contacts
Public ContactDeshbandhu Sood
Citizen Right Protection Forum NGO
Outcome results
None listed