Efficacy and Safety of Low-voltage Guided Ablation for Recurrence Prevention Compared to Pulmonary Vein Isolation Alone in Patients with Persistent Atrial Fibrillation

Conditions

Persistent atrial fibrillation

Okada M, Sakamoto D, Masuda M, Tanaka N, Watanabe T, Minamiguchi H, Egami Y, Oka T, Minamisaka T, Kawasaki M, Makino N, Kanda T, Matsuda Y, Tanaka K, Hirao Y, Miyazaki N, Iwasa K, Kida H, Hikoso S, Sunaga A, Dohi T, Inoue K, Sotomi Y, Sakata Y, OCVC‐Arrhythmia Investigators.

2026-05-25

10.1161/jaha.125.047814

Efficacy of Low-Voltage-Area Ablation Is Enhanced in Patients With Advanced Left Atrial Enlargement: A Subanalysis of the SUPPRESS-AF Trial

Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Hirotaka Ooka, Satoshi Kudo et al. (74 authors)

Circulation Arrhythmia and Electrophysiology2025-09-26

10.1161/circep.125.014210

Additional Low‐Voltage‐Area Ablation in Patients With Paroxysmal Atrial Fibrillation: Results of the Randomized Controlled VOLCANO Trial

Masaharu Masuda, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara et al. (12 authors)

Journal of the American Heart Association2020-06-24104 citations

10.1161/jaha.120.015927

Interventions

Group A: Pulmonary vein isolation Group B: Pulmonary vein isolation with low voltage area ablation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with initial ablation for persistent atrial fibrillation and left atrial low voltage area

Exclusion criteria

Exclusion criteria: Left atrial diameter 55 mm or more History of cardiac surgery Valvular atrial fibrillation Maintenance dialysis Contraindication of ablation Contraindication of anticoagulation therapy Stroke, transient cerebral ischemic attack, systemic embolism in the past 6 months Atrial fibrillation due to treatable factors Pregnancy or possible pregnancy Other cases the doctor considers inappropriate

Design outcomes

Primary

Measure	Time frame
One-year recurrence rate of atrial fibrillation following the first session of catheter ablation	—

Secondary

Measure	Time frame
Atrial fibrillation recurrence rate after the last ablation Death (cause of death) Symptomatic cerebral infarction Ablation-related complications Hemorrhagic complications	—

Countries

Japan

Contacts

Public ContactShungo Hikoso

Osaka University Graduate School of Medicine Department of Cardiovascular Medicine

hikoso@cardiology.med.osaka-u.ac.jp06-6879-3631

Outcome results

None listed