Prospective exploratory study on the effect of oral administration of apixaban in vascular endothelial function in patients with non-valvular atrial fibrillation

Prospective exploratory study on the effect of oral administration of apixaban in vascular endothelial function in patients with non-valvular atrial fibrillation - Prospective study on the effect of apixaban on vascular endothelial function

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035921

Enrollment

Registered

2019-02-18

Start date

2018-05-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-valvular atrial fibrillation patients

Interventions

single arm study, open(masking not used),uncontrolled control, single assignment, treatment purpose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects are 50 patients that consented for consecutive cases of eligible non-valvular atrial fibrillation patients (at least 15 paroxysmal atrial fibrillation cases and at least 15 sustained atrial fibrillation cases). Also, more than 5 subjects with 2 CHADS2 scores and more than 5 subjects with 3 or more CHADSS2 scores are entered respectively.

Exclusion criteria

Exclusion criteria: 1) Patients contraindicated for anticoagulant drug 2) Patients complicated of malignant tumor 3) Patients who have orally ingested anticoagulant within 6 months 4) Patients who judged ineligible from the examining physician

Design outcomes

Primary

Measure	Time frame
vascular endothelial function	—

Secondary

Measure	Time frame
Lab test (General peripheral blood, total protein, albumin, CK, Cr, AST, ALT, gamma-GTP, TG, LDL, HDL, oxidant LDL, hs TNF-alfa, IL-6, Adiponectin, Thrombomodulin, hs CRP, ADMA, Insulin, fibrinogen, D-dimer, TAT, PIC, F1+2, PAI-1, BNP, 8-OHdG/CRE)	—

Countries

Japan

Contacts

Public ContactTaro Adachi

Showa University School of Medicine Division of Cardiology, Department of Medicine

adachitaro@med.showa-u.ac.jp03-3784-8539

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026