Analysis of vonoprazan efficacy against chronic cough in patients with gastroesophageal reflux disease

Analysis of vonoprazan efficacy against chronic cough in patients with gastroesophageal reflux disease - Analysis of vonoprazan efficacy against chronic cough

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035909

Enrollment

Registered

2019-04-01

Start date

2019-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease

Interventions

proton pump inhibitor: vonoprazan

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)chronic non-productive cough 1)presence of heartburn and acid esophagus 2)presence of throat head symptoms such as thrombosis and hoarseness 3)cough worsens with conversation, meal, get up, upper body flexion and weight gain 4)no medications (such as ACE inhibitors) that cause coughing and bronchodilators, inhaled corticosteroids and antiallergic drugs are ineffective (2)over 20 years old (3)written consent form

Exclusion criteria

Exclusion criteria: (1)abnormal findings of chest X-ray (2)history of antacid including proton pump inhibitor (3)allergy to vonoprazan (4)anti-Human Immunodeficiency Virus drugs (5)patients judged inappropriate by physician

Design outcomes

Primary

Measure	Time frame
Japan-Leicester Cough Questionnaire at day 28	—

Secondary

Measure	Time frame
Cough severity visual analogue scale, FSSG questionnaire and adverse events	—

Countries

Japan

Contacts

Public ContactTatsunori Kiriu

Kobe University Graduate School of Medicine Division of Respiratory Medicine, Department of Internal Medicine

tkiriu@med.kobe-u.ac.jp0783825660

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026