Evaluation using in vivo confocal microscopy on ocular surface in patients with dry eye disease related to short tear film breakup time

Evaluation using in vivo confocal microscopy on ocular surface in patients with dry eye disease related to short tear film breakup time - Confocal microscopic findings for dry eye disease related to short BUT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000035886

Enrollment

Registered

2019-02-18

Start date

2019-02-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye disease related to short tear-film breakup time

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult (Over or equal 20 years old) who can be obtained the written informed consent. 2. Subjects Dry eye disease related to short tear-film breakup time.(20 cases) 3. Controls Patients who do not fulfill the criteria for dry eye disease or meibomian gland dysfunction.(20 cases) *Diagnostic criteria for dry eye disease is based on the revised criteria in 2016 by Japanese dry eye disease society.

Exclusion criteria

Exclusion criteria: 1. Difficulty for examination by HRTII-RCM due to the patient's physical and mental condition. 2. Disadvantage by the examination for the patients. 3. No informed consent 4. No ophthalmic surgeries 5. No contact lens wearer 6. No VDT workers more than or equal 4 hours 7. Patients who are not eligible for entry judged by the principal investigators and collaborators in this study.

Design outcomes

Primary

Measure	Time frame
Severity of ocular surface condition (Grading of squamous metaplasia, Density of inflammatory cells and goblet cells, Presence or absence of corneal nerve abnormality)	—

Countries

Japan

Contacts

Public ContactEisuke Shimizu

Keio University School of Medicine Department of Ophthalmology

ophthalmolog1st.acek39@keio.jp0333531211

Outcome results