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Optimal regimens of glucocorticoids tapering for remission induction therapy in patients with severe systemic lupus erythematosus : multi-center randomized open label trial

Optimal regimens of glucocorticoids tapering for remission induction therapy in patients with severe systemic lupus erythematosus : multi-center randomized open label trial - Optimal regimens of glucocorticoids tapering in patients with systemic lupus erythematosus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000035865
Enrollment
100
Registered
2019-02-13
Start date
2019-02-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

systemic lupus erythematosus

Interventions

Dose of glucocorticoids. Rapid tapering group After continuing the initial dose for 2 to 4 weeks, weigh down every 1 week according to the following dose 60 mg, 50 mg, 45 mg, 40 mg, 35 mg, 30 mg,

Sponsors

Juntendo University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients over 20 years old 2) Patients who got consent in writing 3) Patients who met SLE classification criteria or SLICC classification criteria of the American College of Rheumatology 1997 and were diagnosed with SLE in 1997 4) In principle, a combination of immunosuppressive drugs receiving medicine of corticosteroid at a dose of 0.5 mg / kg / day or more and 40 mg / day in terms of prednisolone is used but patients with or without interruption due to side effects etc.

Exclusion criteria

Exclusion criteria: 1) Persons who did not obtain consent 2) Patients with poorly controlled complications 3) Pregnant or lactating women 4) Male and female with pregnancy plan within 52 weeks

Design outcomes

Primary

MeasureTime frame
Relapse free survival rate at week 52.

Countries

Japan

Contacts

Public ContactYoshiyuki Abe

Juntendo University Department of Internal Medicine and Rheumatology

yo-abe@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026