The Utility of Exercise-induced Hyperemia for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis

The Utility of Exercise-induced Hyperemia for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis - Exercise-induced Hyperemia for the Measurement of Fractional Flow Reserve

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035785

Enrollment

Registered

2019-02-08

Start date

2019-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

angina pectoris

Interventions

2mg of intracoronary nicorandil 2mg of intracoronary nicorandil after dynamic handgrip contraction (1/s) for 90s at 60% maximal voluntary contraction

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have at least one of 50 to 90% focal stenosis in the coronary artery on diagnostic coronary angiography.

Exclusion criteria

Exclusion criteria: acute coronary syndrome significant left main disease lesion with chronic total occlusion or collateral vessel previous coronary artery bypass surgery severe valvular disease low ejection fraction severe renal dysfunction or hemodialysis contraindications of exercise

Design outcomes

Primary

Measure	Time frame
FFR value measured by exercise-induced hyperemia compared with drug-induced hyperemia	—

Secondary

Measure	Time frame
heart rate, blood pressure, and cardiac ultrasound data before and after exercise	—

Countries

Japan

Contacts

Public ContactHiroki Shibutani

Kansai Medical University Department of Medicine 2

hs.vxvii@gmail.com072-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026