Study on the influence of cardiac output on blood concentration during continuous administration of fentanyl

Study on the influence of cardiac output on blood concentration during continuous administration of fentanyl - Study on the influence of cardiac output on blood concentration during continuous administration of fentanyl

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000035777

Enrollment

Registered

2019-02-05

Start date

2019-02-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disease that is performed a free flap under general anesthesia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients who are over 20 years of age at consent acquisition 2.Patients with ASA-PS 1 to 3 3.After receiving sufficient explanation for the participation of this study, patients who obtained document consent by the patient's free will with sufficient understanding

Exclusion criteria

Exclusion criteria: 1.Patient who did not obtain consent 2.Patients allergic to fentanyl 3.Patients with BMI> 30 4.Pregnant women / lactating women 5.Patients with liver failure / renal failure

Design outcomes

Primary

Measure	Time frame
Correlation between the ratio or difference between blood concentration predicted by Shafer model and actual blood concentration of fentanyl and cardiac output or cardiac index	—

Secondary

Measure	Time frame
Change of cardiac output using dopamine Change of concentration of fentanyl and its metabolites Measurement of activity of CYP3A (measurement of blood concentration of midazolam and metabolites)	—

Countries

Japan

Contacts

Public ContactTatsunori Watanabe

Niigata University Medical & Dental Hospital Department of Anesthesiology

deepimpact034@yahoo.co.jp025-223-2328

Outcome results