Noncoding RNA related to pain of osteoarthritis: Does miR-21 relate to osteoarthritic pain?

Noncoding RNA related to pain of osteoarthritis: Does miR-21 relate to osteoarthritic pain? - Involvement of miR-21 in osteoarthritic pain

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000035774

Enrollment

Registered

2019-02-04

Start date

2019-02-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who visited the department of orthopaedic surgery of Nippon Medical School are considered for trial recruitment. Eligibility criteria also includes an age of at least 20 years and any of following criteria. (1) Patients with Kellgren-Lawrence classifications III-IV knee OA who take arthrocentesis of knee in outpatient clinic and whose pain VAS score is less than 50mm (2) Patients without knee OA who take arthroscopic surgery and whose pain VAS score is less than 50mm (3) Patients with knee OA who take knee replacement

Exclusion criteria

Exclusion criteria: (1) Patients who do not consent for this research (2) Patients who have psychiatric disorder (3) Patients who can not answer questionnaire for pain due to dementia and others

Design outcomes

Primary

Measure	Time frame
Correlation of miR-21 expression in synovium and synovial fluid of OA patients and Knee Injury and Osteoarthritis Outcome Score(KOOS) Pain Score	—

Secondary

Measure	Time frame
(1) Correlation of miR-21 expression in synovium and synovial fluid of OA patients and Pain VAS score (2) miR-21 expression of each group	—

Countries

Japan

Contacts

Public ContactNaoya Hoshikawa

Nippon Medical School Department of Orthopaedic Surgery

hoshikawa-nms@umin.ac.jp+81-3-3822-2131

Outcome results