Chronic graft-versus-host disease (GVHD)-related dry eye disease after hematopoietic stem cell transplantation
Conditions
Interventions
None listed
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adult over 20 years old who is attending dry eye clinic at Keio University Hospital 2) Written informed consent 3) Patients who have newly developed dry eye disease (i.e. chronic GVHD-related dry eye disease) after hematopoietic stem cell transplantation (HSCT). 4) Patients who did not develop dry eye disease after HSCT. 5) Patients who did not have dry eye disease before HSCT. Eligible for the patients who can be recruited is to fulfill the above number of 1) 2)3)or 1)2)4) or 1)2)5) Diagnostic criteria for dry eye by Japanese Dry Eye Society 2006
Exclusion criteria
Exclusion criteria: 1) No written informed consent 2) No other autoimmune disease 3) No allergic conjunctivitis, ocular surface infectious disease, nor contact lens wearer 4) No dry eye disease before hematopietic stem cell transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterization of microbiota for chronic GVHD-related dry eye disease compared with the controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional expectation of ocular surface and intestinal microbiome depending on the severity of chronic GVHD-related dry eye disease. | — |
Countries
Japan
Contacts
Public ContactEisuke Shimizu
Keio University Schol of Medicine Department of Ophthalmology
Outcome results
None listed