Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol for children with food allergy

Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol for children with food allergy - Analysis of the efficacy of oral immunotherapy combined with brown rice-specific gamma-oryzanol

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035603

Enrollment

Registered

2019-01-21

Start date

2019-01-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food allergy

Interventions

Patient ingests brown rice-specific gamma-oryzanol for 1 year

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who failed low-dose oral food challenge Low-dose was defined as "one eight of whole egg, 3 ml of cow's milk, 2g of Udon (Japanese wheat noodles), 0.5g of whole peanut or 0.5g of nut".

Exclusion criteria

Exclusion criteria: Decision of ineligibility by a physician

Design outcomes

Primary

Measure	Time frame
Sustained unresponsiveness to middle-dose after 12 months. Middle dose was defined as "half of a whole egg, 25 ml of cow's milk, 25g of Udon, 3g of peanut or 3g of nut".	—

Secondary

Measure	Time frame
Intestinal microbiota Short chain fatty acids (Acetic acid, butyric acid, propionic acid, valeric acid) in serum Changes of specific IgE, IgG, IgG4 Frequency of adverse reactions	—

Countries

Japan

Contacts

Public ContactKen-ichi Nagakura

National Hospital Organization Sagamihara National Hospital Department of pediatrics

k.nagakura@foodallergy.jp042-742-8311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026