The efficacy of continuous administration of low-dose ketamine during elective on-pump cardiac surgery on hospital length of stay. A Randomised Controlled Trial

The efficacy of continuous administration of low-dose ketamine during elective on-pump cardiac surgery on hospital length of stay. A Randomised Controlled Trial - The efficacy of continuous administration of low-dose ketamine during elective on-pump cardiac surgery on hospital length of stay. A Randomised Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035517

Enrollment

Registered

2019-01-11

Start date

2019-01-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular heart disease and ischaemic heart disease

Interventions

control group continuous administration of low-dose ketamine group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Elective valve surgery (mitral valve/aortic valve) and/or coronary artery bypass surgery with a cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: Emergency surgery Redo Minimally invasive cardiac surgery carrying ICD patients who have been diagnosed with cancer ASA PS 4, 5, 6 Uncontrolled diabetes mellitus Severe pulmonary diease, asthmatic attack Current smoker Hepatic impairment (Child-Pugh A,B,C or aspartate aminotransferase or alanine aminotransferase more than twice the upper normal limit) Chronic renal insufficiency:serum creatinine level > 2 mg/dL Immunosuppressive medication (e.g. glucocorticoids) Cognitive dysfunction, Psychiatric impairment, depression, Parkinson disease, Cerebrovascular disease

Design outcomes

Primary

Measure	Time frame
the hospital length of stay after surgery	—

Secondary

Measure	Time frame
Occurrence of delirium Occurrence of postoperative atrial fibrillation	—

Countries

Japan

Contacts

Public ContactGeneral Affairs Department Saitama Cardiovascular and Respiratory Centre

Saitama Cardiovascular and Respiratory Centre General Affairs Department

k369900@pref.saitama.lg.jp048-536-9900

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026