food protein-induced enterocolitis syndrome
Conditions
Interventions
None listed
Sponsors
National Hospital Organization Sagamihara National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients included in the study will be either A) or B) A) Patients who are diagnosed with hen's egg-induced FPIES by meeting the major criterion and 3 or more minor criteria. B) Patients who are suspected of hen's egg-induced FPIES by meeting the major criterion but meet less than 3 minor criteria. Major criterion: Vomiting in the 1-4 hour period after ingestion of the suspected food and the absence of classic IgE-mediated allergic skin or respiratory symptoms. Minor criteria: 1. A second (or more) episode of repetitive vomiting after eating the same suspected food. 2. Repetitive vomiting episode 1-4 hours after eating a different food. 3. Extreme lethargy with any suspected reaction 4. Marked pallor with any suspected reaction 5. Need for emergency department visit with any suspected reaction 6. Need for intravenous fluid support with any suspected reaction 7. Diarrhea within 24 hours 8. Hypotension 9. Hypothermia
Exclusion criteria
Exclusion criteria: Patients with immediate-type hen's egg allergy. Patients who are determined not suitable to participate in the study by the attending physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients that have acquired tolerance to hen's egg at the age of 5 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in egg white, egg yolk, ovomucoid specific IgE levels. The change in wheal size of skin prick tests with egg white and egg yolk. The rate of atopic dermatitis, asthma, allergic rhinitis, and food allergy to foods other than hen's egg at the age of 5 years. | — |
Countries
Japan
Contacts
Public ContactMakoto Nishino
National Hospital Organization Sagamihara National Hospital Department of Pediatrics
Outcome results
None listed