Effects of isometric handgrip exercise on hemodynamics and left ventricular function

Effects of isometric handgrip exercise on hemodynamics and left ventricular function - Handgrip exercise study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035385

Enrollment

Registered

2018-12-27

Start date

2015-08-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure

Interventions

3 minutes of isometric handgrip exercise and 3 minutes of postexercise circulatory arrest

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. no heart failure symptom at supine position. 2. heart failure with reduced ejection fraction (less than 40 percent, n=10), and heart failure with preserved ejcetion fraction (n=10)

Exclusion criteria

Exclusion criteria: 1) unstable AP 2) myocardial infraction with 6 months 3) AF/AFL 4) severe valvular disease 5) Resting SBP>160mmHg or PCWP>25mmHg 6) exercise training > 3times per week 7) percemaker, ICD, CRTD 8) renal dysfunction

Design outcomes

Primary

Measure	Time frame
Blood pressure, left ventricular enddiastolic and endsystolic pressure, and heart rate during isometric handgrip exercise and postexercise circulatory arrest.	—

Secondary

Measure	Time frame
Left ventricular systolic and diastolic function, left ventricular morphology and function by echocardiogram, muscle strength, right ventricular hemodynamics, six minute walk distance, blood test.	—

Countries

Japan

Contacts

Public ContactNaoki Fujimoto MD, PhD

Mie University Graduate School of Medicine Department of Cardiology and Nephrology

naokifujimo@clin.medic.mie-u.ac.jp059-232-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026