Respiratory tract infection/atypical pathogen/Mycoplasma pneumoniae/Chlamydophila pneumoniae/Bordetella pertussis/Bordetella paraperutussis
Conditions
Interventions
None listed
Sponsors
Tsukuba Medical Center Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients are eligible for this study if all of the following criteria are met: 1) Patients are able to provide written informed consent 2) Patients have both fever (one degree higher than normal body temperature or body temperature > 37 degrees Celsius) and cough, one of which persists at least three days 3) Patients are treated by the study investigators
Exclusion criteria
Exclusion criteria: Patients are excluded if one of the following criteria is met. 1) Patients or proxies are unable to provide informed consent in Japanese 2) Patients have severe conditions (e.g., altered mental status and shock state), and sample collections are unable to be performed safely 3) Patients have chronic lung disease with multiple episodes of acute exacerbation 4) Patients have clinically evident sinusitis or tonsillitis with tonsillar exudate and swelling 5) Patients have lung tuberculosis, lung mycosis, or nontuberculous mycobacterial lung disease 6) Patients are diagnosed with hospital-acquired pneumonia or healthcare-associated pneumonia 7) Patients have dysphagia or a history of aspiration 8) Patients have obstructive pneumonia, empyema, or lung abscess
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The epidemiological characteristics of respiratory tract infection caused by atypical pathogens (Mycoplasma pneumoniae, Chlamydophila pneumoniae, Chlamydophila psittasi, Bordetella pertussis, Bordetella parapertussis). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The sensitivity, specificity, positive/negative predictive value, and odds ratio of the clinical signs and symptoms for the diagnosis of respiratory infection caused by different atypical pathogens. 2) The agreement between the clinical disease probabilities of atypical pathogen infection assessed by the treating physicians and the results of molecular examinations. 3) The changes in the reliability of disease probabilities assessed by the treating physicians during the study period. 4) The differences in the antimicrobial prescription patterns between patients with positive and negative test results for atypical pathogens. 5) The differences in the antimicrobial prescription patterns between Mycoplasma pneumoniae patients with and without the macrolide resistance associated mutation. 6) The sensitivity, specificity, positive/negative predictive value and odds ratio of the Heckerling clinical decision rule for the diagnosis of community-acquired pneumonia. | — |
Countries
Japan
Contacts
Public ContactHiromichi Suzuki
Tsukuba Medical Center Hospital Division of Infectious Diseases, Department of Medicine
Outcome results
None listed