healthy adults
Conditions
Interventions
visit 1, 3 inhalation of methacholine visit 2 inhalation of capsaicin
Sponsors
Kanazawa University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1: subjects with aged 20 years or older 2; subjects without history of respiratory disease and symptoms 3; subjects who can get documentary consent by one's own free will after enough informed consent 4; subjects with NLHQ is less than 17.1.
Exclusion criteria
Exclusion criteria: 1; subjects with cardiovascular disease, liver / biliary tree disease, digestive organ disease, immune disease or malignant tumor etc 2; subjects with a low pulmonary function whose 1 second amount is 1 L or less 3; subjects with the risk of pneumothorax and mediastinal emphysema 4: subjects who are allergic to capsaicin 5; pregnant or having a possibility of pregnancy 6; subjects who is lactating 7; Others who judged inappropriate by other research researcher or research sharing doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between the cough response induced by methacholine inhalation and a sensation in the throat. Correlation between the cough reflex sensitivity to inhaled capsaicin and a sensation in the throat. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in a sensation in the throat caused by inhaled methacholine and capsaicin. | — |
Countries
Japan
Contacts
Public ContactJohsuke Hara
Kanazawa University Hospital Respiratory medicine
Outcome results
None listed