Study of the effect of a drink containing lactic acid bacteria on bowel movement, intestinal flora and fecal properties in subjects with constipation tendency. : A randomized, double blinded, placebo controlled study

Study of the effect of a drink containing lactic acid bacteria on bowel movement, intestinal flora and fecal properties in subjects with constipation tendency. : A randomized, double blinded, placebo controlled study - Study of the effect of a drink containing lactic acid bacteria on bowel movement,intestinal flora and fecal properties in subjects with constipation tendency.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035202

Enrollment

100

Registered

2018-12-10

Start date

2018-12-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult

Interventions

Ingestion of test product for 2 consecutive weeks Ingestion of placebo for 2 consecutive weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)males and females from 20 to 64 years of age (2)Subjects who answered that the usual defecation frequency was 5 or less per week in the questionnaire (3)Subjects with constipation tendency and lower defecation frequency during screening period

Exclusion criteria

Exclusion criteria: (1)Subjects who cannot restrict the use of medicines or health foods that may influence their bowel movements after informed consent (2)Subjects visiting the hospital for diseases related bowel movements and using drugs, or are regularly using commercially available constipation medicine (3)Subjects currently undergoing treatment or with digestive diseases that affect the study or have a surgical history of digestive system(except appendicectomy) (4)Subjects with diseases (irritable enteritis, ulcerative colitis,etc.) affecting bowel movement or have a history of these diseases (5)Subjects who are under treatment or have a history of serious disease(e.g., diabetes, liver disease, kidney disease, or heart disease) (6)Subjects judged as unsuitable for this study based on the results of clinical examination or cardiopulmonary abnormality (7)Subjects have a deseases requiring regular medication or a history of serious diseases for which medication was required (8)Subjects have possibilities to develop an allergy to the test product (9)Subjects who are judged as unsuitable for the study based on the results of lifestyle questionnaire (10)Subjects who are judged as unsuitable for the study based on the results of clinical and physical examination on preliminary examination (11)Subjects who have participated in other clinical studies (12)Subjects who are planned to become pregnant after informed consent for the current study or are pregnant or lactating (13)Subjects judged as unsuitable for the study by the investigator for other reasons

Design outcomes

Primary

Measure	Time frame
Defecation frequency Evaluate two weeks after starting ingestion.	—

Secondary

Measure	Time frame
Defecation days, Fecal amount, Fecal properties. Intestinal flora(Real-Time PCR). Fecal moisture. Fecal pH. The fecal concentrations of ammonia.	—

Countries

Japan,South America

Contacts

Public ContactChiharu Goto

TTC Co., Ltd. Clinical Research Planning Department

c.goto@ttc-tokyo.co.jp03-5459-5329

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026