Clinical study of minimally invasive transplantation of autologous chondrocytes products (ACP) for cartilage repair for the knee joint

Clinical study of minimally invasive transplantation of autologous chondrocytes products (ACP) for cartilage repair for the knee joint - Clinical study of minimally invasive transplantation of autologous chondrocytes products (ACP) for cartilage repair for the knee joint

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035151

Enrollment

Registered

2018-12-10

Start date

2019-02-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Focal cartilage defect of the knee joint caused by trauma and/or early osteoarthritis

Interventions

Chondrocytes are obtained from unloaded part of patient&#39

s cartilage and cultured through passaging. The chondrocytes mixed with hydrogel are transplanted under arthroscopy or minimal open surgery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with symptomatic pain of the knee who has focal chondral defect detectable by MRI. Patients with chondral defect of ICRS III/IV or Outerbridge-Brittberg III/IV. The size of chondral defect:2-9cm2.

Exclusion criteria

Exclusion criteria: Patients with 1.advanced osteoarthritis KL grade II and above with narrowing of the gap of knee joint, 2.arthritis with autoimmune disease such as Rheumatoid arthritis, 3.abnormal alignment of lower extremity, 4.infectious disease (HIV/HBV/HCV/HTLV etc.).

Design outcomes

Primary

Measure	Time frame
Clinical evaluation (Improvement of KOOS (Knee injury and Osteoarthritis Outcome Score) from baseline)	—

Secondary

Measure	Time frame
Clinical evaluation, MRl, Arthroscopy, Pathological evaluation and Activity evaluation. Frequency and content of adverse events.	—

Countries

Japan

Contacts

Public ContactTakashi Kanamoto

Osaka University Graduate School of Medicine Medicine for Sports and Performing Arts

takanamoto@hss.osaka-u.ac.jp0662108439

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026