Clinical study on the monitoring of heparin concentration and patient prognosis in cardiac surgery under cardiopulmonary bypass

Clinical study on the monitoring of heparin concentration and patient prognosis in cardiac surgery under cardiopulmonary bypass - Clinical study on the monitoring of heparin concentration and patient prognosis in cardiac surgery under cardiopulmonary bypass

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000035112

Enrollment

Registered

2018-12-04

Start date

2018-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac surgery under cardiopulmonary bypass

Interventions

Administration of heparin based on ACT during cardiopulmonary bypass Administration of heparin administered by keeping the blood heparin concentration fixed during cardiopulmonary bypass

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing elective cardiac surgery with cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: 1. Under 20 years old 2. Emergency operation 3. Major vascular surgery (circulatory arrest, selective cerebral perfusion) 4. Infective endocarditis 5. Patients with coagulation fibrinolysis abnormality by preoperative examination 6. Patient using auxiliary circulation before surgery

Design outcomes

Primary

Measure	Time frame
Amount of blood loss	—

Secondary

Measure	Time frame
Amount of blood transfusion, heparin dosage, protamine dosage, time to extubation, length of ICU stay, blood coagulation and fibrinolysis function, anti-inflammatory effect, artificial lung inlet pressure and artificial lung outlet pressure	—

Countries

Japan

Contacts

Public ContactMikiko Tomino

Tokyo Medical University Hachioji Medical Center Department of Anesthesiology

mikikong30@gmail.com042-665-5611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026