To clarify the relation between NHO voice therapy and Substance P (Exploring the Relation between Glottal Closure and Plasma Substance P)

To clarify the relation between NHO voice therapy and Substance P (Exploring the Relation between Glottal Closure and Plasma Substance P) - NHO voice therapy(Vocal / swallowing disorder training) and Substance P

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000035080

Enrollment

180

Registered

2018-12-13

Start date

2018-12-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glottal incompetence, vocal fold atrophy aged

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. equal and more than 65years old 2.Patient complained breathy hoarseness, cough or dysphagia. 3.Agree with NHO voice therapy 4.understood the clinical research 5.Patients has no Neuropsychi-atric disorders 6.No inflammation, tum-or paralysis, polyp, glanuloma etc. on patients vocal fold. 7.vocal fold atrohy in both side and recognized glottal incompetence 8.possible to visit hospital. 9. responsible physician in each hospital agreed with the indication of voice therapy.

Exclusion criteria

Exclusion criteria: 1. Patient could not understand Japanese or could not record training diary. 2. Patient cloud not perform voice therapy. 3. Value of the maximum phonation time was equal and more than 15 seconds.

Design outcomes

Primary

Measure	Time frame
Maximum phonation time (MPT),Comparison with Substance P before the voice therapy and after 6-months voice therapy.	—

Countries

Japan

Contacts

Public ContactKoichi Tsunoda, MD.PhD

National Hospital Organization Clinical Research Center Sensory Center Artificial organ / device development research department

koichi.tsunoda@kankakuki.jp+81-3-3411-0111

Outcome results