Ulcerative Colitis
Conditions
Interventions
None listed
Sponsors
Nagasaki University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Target disease: refractory ulcerative colitis of moderate or more 2. Age: patients over 20 years old and under 75 years old 3. Gender: No prejudice 4. After receiving sufficient explanation for participation in the research, after sufficient understanding, freedom of the subject himself / herself Patient who obtained document consent by intention.
Exclusion criteria
Exclusion criteria: 1. Patients with severe liver and kidney dysfunction 2. Patients with a history of drug hypersensitivity such as allergy to the ingredients of this drug 3. Pregnant women and patients who may be pregnant or breast-feeding 4. Other patients who have been judged inappropriate as research subjects by research managers (including colorectal biopsy cases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between the amount of phosphorylated STAT change in colonic mucosa before treatment and 4 weeks after treatment and the change in disease activity before treatment and 16 weeks after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Correlation between oncostatin M change in colonic mucosa before treatment and 4 weeks after treatment and disease activity change before treatment and after 16 weeks of treatment 2.Correlations between changes in peripheral blood oncostatin M, IL-6, TNF-alpha, IFN-gamma before and 4 weeks before treatment and disease activity change before and after treatment 16 3.In the comprehensive analysis of colonic mucosal microRNA before treatment and after 4 weeks, it is an item to be collected exploratory and there is a possibility of setting additional items due to future research and clinical course. | — |
Countries
Japan
Contacts
Public ContactRikako Kinoshita
Nagasaki University Hospital Gastroenterology
Outcome results
None listed