Healthy adults
Conditions
Interventions
Daily intake of 1 capsule containing heat-killed Lactobacillus plantarum HOKKAIDO for 8 weeks.
Daily intake of 1 capsule containing dextrin for 8 weeks.
Sponsors
Hokkaido Information University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Subjects who agree to participate in this study with a written informed consent. 2.Subjects who show relatively low NK cell activity
Exclusion criteria
Exclusion criteria: 1.Subjects with serious diseases and/or infections. 2.Subjects with major surgical history relevant to the digestive system such as gastrectomy, gastrorrhaphy, enterectomy, etc. 3.Subjects with unusually high and/or low blood pressure and/or abnormal hematological data. 4.Subjects with severe anemia. 5.Pre- or post-menopausal women complaining of obvious physical changes. 6.Subjects who are at risk of having allergic reactions to drugs or foods. 7.Subjects who regularly intake products containing HOKKAIDO-strain. 8.Subjects who regularly take medicine, functional foods, and/or supplements which would affect immune function. 9.Heavy smokers, alcohol addicts or subjects with disordered lifestyle. 10.Subjects who donated either 400 ml whole blood within 16 weeks (women), 12 weeks (men), 200 ml whole blood within 4 weeks (men and women), or blood components within 2 weeks (men and women), prior to the current study. 11.Pregnant or lactating women or women who expect to be pregnant during this study. 12.Subjects who currently participate in other clinical trials, or participated within the last 4 weeks prior to the current study. 13.Any other medical and/or health reasons unfavorable to participation in the current study, as judged by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NK-cell activity at 4 and 8 weeks after beginning the intake of test food. | — |
Secondary
| Measure | Time frame |
|---|---|
| IgA, IgG, IgM, neutrophils, lymphocytes, monocytes, eosinophils, basophils, neutrophil-lymphocyte ratio, salivary s-IgA VAS questionnaire assessed condition of gastrointestinal tract and fatigue, frequency of common cold symptoms. | — |
Countries
Japan
Contacts
Public ContactJun NISHIHIRA
Hokkaido Information University Health Information Science Research Center
Outcome results
None listed