At-Risk Mental State (ARMS) First Episode Psychosis
Conditions
Interventions
Magnetic Resonance Imaging (MRI) Magnetic Resonance Spectroscopy (MRS)
Magnetic Resonance Imaging (MRI) Magnetic Resonance Spectroscopy (MRS)
Magnetic Resonance Imaging (MRI) Magnetic Resonance
Sponsors
Department of Psychiatry, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: at risk mental state (ARMS) A) Those who meet ARMS criteria at the PACE clinic B) Within two years after first meeting ARMS criteria C) no history of psychosis that meet psychosis criteria at PACE clinic D) age 14-39 years E) native Japanese speaker F) Those who have no decline in judgment ability by psychotic symptoms and obtain written informed consent to this study by themselves (in the case of minors, even from person in parental authority) first episode psychosis (FEP) A) Those who meet criteria of the DSM-IV for schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder,psychotic disorder not otherwise specified, major depressive disorder with psychotic features, or bipolar disorder with psychotic features; confirmed by the Mini International Neuropsychiatric Interview (MINI) B) Within two years after first diagnosis of psychosis C) age 14-39 years D) native Japanese speaker E) Those who have no decline in judgment ability by psychotic symptoms and obtain written informed consent to this study by themselves (in the case of minors, even from person in parental authority) healthy control A) Those who have no history of mental disorders and do not correspond to mental disorder in MINI B) age 14-39 years C) native Japanese speaker D) Those who have no decline in judgment ability by psychotic symptoms and obtain written informed consent to this study by themselves (in the case of minors, even from person in parental authority)
Exclusion criteria
Exclusion criteria: A) history of neurological disorders, head injury, or any other significant medical condition associated with psychiatric symptoms B) substance use disorder C) intellectual disability D) exclusion criteria to MRI: presence of a pacemaker, metallic implants, claustrophobia (exclusion criteria for only the research part related to MRI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GAF Global Function transition to psychosis | — |
Secondary
| Measure | Time frame |
|---|---|
| whole-brain gray matter volume, whole-brain white matter volume metabolic level in hippocampus CTQ, CAARMS, PANSS, PSYRATS-J, JCDSS, BDI-II, PCL, AQ-J, LSAS, QPR-J, BACS, WCST, CBQp | — |
Countries
Japan
Contacts
Public ContactYutaro Sato
Tohoku University Graduate School of Medicine Department of Psychiatry
Outcome results
None listed