Esophageal squamous cell carcinoma
Conditions
Interventions
None listed
Sponsors
Grant-in-Aid for Scientific Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Newly diagnosed early squamous cell carcinoma of the esophagus. (2) Complete endoscopic resection (ER) as assessed visually on Lugol chromoendoscopy immediately after ER. (3) A diagnosis of squamous cell carcinoma on histopathological examination of the resected specimen. (4) Vertical margins of the resected specimen are confirmed to be tumor-negative. (5) Tumor invasion is limited to the mucosa on histopathological examination of the resected specimen, and no additional treatment (surgical resection, radiotherapy, chemotherapy, etc.) is performed immediately after ER. (6) No active head or neck cancers. (7) The investigator judges that patient can be observed for at least 2 years. (8) Written informed consent is obtained from the patient.
Exclusion criteria
Exclusion criteria: (1) A history of chemotherapy for any other cancers or a history of surgical treatment or radiotherapy for head and neck cancers. (2) A history of iodine allergy. (3) Patients whom the investigator considers unsuitable as subjects for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cumulative incidence of metachronous cancers as assessed by the Lugol-voiding pattern and ALDH2/ADH1B/CYP2A6 gene polymorphism | — |
Secondary
| Measure | Time frame |
|---|---|
| The total annual number of cases of metachronous cancers as assessed by the Lugol-voiding pattern and ALDH2/ADH1B/CYP2A6 gene polymorphism | — |
Countries
Japan
Contacts
Public ContactChikatoshi Katada
Kitasato University School of Medicine Department of Gastroenterology
Outcome results
None listed