Preventive effect of post-ERCP pancreatitis by cooling the duodenal papilla with ice water

Preventive effect of post-ERCP pancreatitis by cooling the duodenal papilla with ice water - Ice water challenge

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034710

Enrollment

100

Registered

2018-12-01

Start date

2018-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallbladder cancer / bile duct cancer / pancreatic cancer / bile duct stone / cholangitis / pancreatitis / pancreatic cyst / pancreatic duct stenosis / biliary dilatation etc.

Interventions

Before ending with ERCP, ice water is injected endoscopically into the lower duodenum to cool the duodenal papilla. Injection method uses a jet water pump, inject 250 ml of cold water.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ERCP can be enforced, there is no history of nipple treatment was enforced. The age at registration is over 20 years old. After getting enough explanation about participation in research, with sufficient understanding, written consent was obtained from the research subject himself / herself by the free will of the person him / herself.

Exclusion criteria

Exclusion criteria: Patient with a history of ERCP Patient in postoperative reconstructed intestinal tract (Except for billroth-I) Patients with acute pancreatitis Patients who require drinking restriction due to heart failure etc. Patients who are judged inappropriate for the research director or the attending physician to conduct this study

Design outcomes

Primary

Measure	Time frame
Incidence of post-ERCP pancreatitis	—

Secondary

Measure	Time frame
Patient background (age, sex, past history of pancreatitis, PS, ASA, drinking history, smoking history etc.). Presence or absence of cholangitis before treatment. PEP incidence rate due to differences in ERCP procedures (bile duct obesity, pancreatic ductal purpose, EST, EPBD, biopsy, IDUS, biliary stent, pancreatic duct stent, etc.). PEP incidence rate with or without pancreatic ductal intubation/ ductography. PEP incidence rate due to bile duct intubation time. Increase frequency and degree of pancreatic enzyme and inflammatory reaction (WBC, CRP) after 2 hours of ERCP/ next day in the above items. The degree of PEP in the above items.	—

Measure

Time frame

Patient background (age, sex, past history of pancreatitis, PS, ASA, drinking history, smoking history etc.). Presence or absence of cholangitis before treatment. PEP incidence rate due to differences in ERCP procedures (bile duct obesity, pancreatic ductal purpose, EST, EPBD, biopsy, IDUS, biliary stent, pancreatic duct stent, etc.). PEP incidence rate with or without pancreatic ductal intubation/ ductography. PEP incidence rate due to bile duct intubation time. Increase frequency and degree of pancreatic enzyme and inflammatory reaction (WBC, CRP) after 2 hours of ERCP/ next day in the above items. The degree of PEP in the above items.

—

Countries

Japan

Contacts

Public ContactShunjiro Azuma

Kitano Hospital Tazuke Kofukai Medical Research Institute Gastroenterology and hepatology

s-azuma@kitano-hp.or.jp06-6312-1221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026