Effect on liver following metabolic surgery in patients with fatty liver and type 2 diabates -Prospective cohort study-

Effect on liver following metabolic surgery in patients with fatty liver and type 2 diabates -Prospective cohort study- - Effect on liver by metabolic surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000034667

Enrollment

Registered

2018-12-01

Start date

2018-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with fatty liver and type 2 diabates

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients whose BMI is more than 35 kg/m2 in operative group and more than 30 kg/m2 in control group 2) Patients who are 20-year-old or older 3) Patients suspected NASH/NAFLD 4) Patients who are able to understand the study and willing to provide written informed consent

Exclusion criteria

Exclusion criteria: 1) Patients who are deemed to be unsuitable by the investigator

Design outcomes

Primary

Measure	Time frame
Change of hepatic steatosis and fibrosis in the blood test and image examination	—

Secondary

Measure	Time frame
1) Body weight, BMI and waist circumference 2) Total weight loss rate and excess weight loss rate 3) Blood pressure 4) Fasting plasma glucose 5) Adiponectin and reptin 6) Other blood and urine tests (liver, kidney, lipid, bone metabolism, nutrition, endocrine, etc) 7) Visceral fat mass and subcutaneous fat mass (HDS-2000 DUALSCAN) 8) Visceral fat mass and subcutaneous fat mass (computed tomography) 9) Body composition (InBody) 10) Dual-energy X-ray absorptiometry 11) Hepatic hepatosis and fibrosis index (calculation from blood tests) 12) Insulin kinetics with 75gOGTT 13) Liver biopsy	—

Measure

Time frame

1) Body weight, BMI and waist circumference 2) Total weight loss rate and excess weight loss rate 3) Blood pressure 4) Fasting plasma glucose 5) Adiponectin and reptin 6) Other blood and urine tests (liver, kidney, lipid, bone metabolism, nutrition, endocrine, etc) 7) Visceral fat mass and subcutaneous fat mass (HDS-2000 DUALSCAN) 8) Visceral fat mass and subcutaneous fat mass (computed tomography) 9) Body composition (InBody) 10) Dual-energy X-ray absorptiometry 11) Hepatic hepatosis and fibrosis index (calculation from blood tests) 12) Insulin kinetics with 75gOGTT 13) Liver biopsy

—

Countries

Japan

Contacts

Public ContactOe Yuki

Hokkaido University Graduate School Department of Rheumatology, Endocrinology and Nephrology

o-e.yuki@med.hokudai.ac.jp011-706-5915

Outcome results