Effects of dl-methylephedrine on dopamine transporter in healthy adulgs using PET: randomized, placebo-controlled, double-blind, comparative study

Effects of dl-methylephedrine on dopamine transporter in healthy adulgs using PET: randomized, placebo-controlled, double-blind, comparative study - methylephedrine DAT study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034612

Enrollment

Registered

2018-10-24

Start date

2018-10-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adults

Interventions

1) PET, MRI 2) single dose administration, dl-methylephedrine 60mg, PET 3) washout duration 1 week 4) single dose administration, placebo, PET 1) PET, MRI 2) single dose administration, placebo, P

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Subjects with no history of psychiatric disorders. Subjects with normal BMI (18.5-25). Subjects without the history of smoking. Subjects who have the ability to provide informed consent and adhere to the protocol.

Exclusion criteria

Exclusion criteria: Subjects with drug allergy. Subjects taking drugs within 2 weeks of the trial. Subjects with hyperthyroidism, hypertension, heart disease, diabetes, severe asthma or hypoxemia. Subject who is contraindicated for the use of MRI. Subject without the history of smoking. Subject who are judged as not suitable for participation in this study.

Design outcomes

Primary

Measure	Time frame
binding potential of dopamine transporter 2 hours after administration of dl-methylephedrine	—

Secondary

Measure	Time frame
blood and/or urine concentration, MRI	—

Countries

Japan

Contacts

Public ContactAmane Tateno

Nippon Medical School Department of Neuropsychiatry

amtateno@nms.ac.jp+81-3-3822-2131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026