Detection of Ruptured plaques as Embolic source in Aorta to clarify the Mechanism of systemic organ deterioration by Non-Obstructive General Angioscopy

Detection of Ruptured plaques as Embolic source in Aorta to clarify the Mechanism of systemic organ deterioration by Non-Obstructive General Angioscopy - Relationship between aortic plaques and organ insufficiency: DREAM NOGA study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000034588

Enrollment

500

Registered

2018-11-01

Start date

2018-07-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease or suspected

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patient who received CAG or PCI with confirmed or suspected of cardiovascular disease underwent 2) patient who received non-obstructive general angioscopy 3) Patients who clinically have high risk of occurrence of aortic disease and aortic CT examination is useful for patients 4) Patients who clinically have high risk of occurrence of cerebral infarction and brain MRI is useful for patients high risk of occurrence of cerebral infarction was defined as 1) neurological symptom, 2)atherosclerotic factors, and aortic calcification with Xray or CT 5) >= 20 years old, male and female 6) written informed consent

Exclusion criteria

Exclusion criteria: 1) anaphylactic shock by contrast medium 2) metal in the body 3) Claustrophobia 4) pregnancy or breast-feeding 5) cardiogenic shock 6) acute aortic dissection or rupture of aortic aneurysm, or impending state of them 7) appropriate patients decided by the doctor

Design outcomes

Primary

Measure	Time frame
1.the relationship between the quality of aortic plaques and the increase of cerebral infarction with MRI 2.the relationship between the quality of aortic plaques and the increase of urinary albumin creatinin ratio 3.the relationship between the quality of aortic plaques and the change of ABI value and sarcopenia score 4.the relationship between aortic plaques and the occurrence of acute aortic dissection	—

Measure

Time frame

1.the relationship between the quality of aortic plaques and the increase of cerebral infarction with MRI 2.the relationship between the quality of aortic plaques and the increase of urinary albumin creatinin ratio 3.the relationship between the quality of aortic plaques and the change of ABI value and sarcopenia score 4.the relationship between aortic plaques and the occurrence of acute aortic dissection

—

Secondary

Measure	Time frame
1.the relationship between the frequency of aortic plaques and the increase of cerebral infarction with MRI 2.the relationship between the frequency of aortic plaques and the increase of urinary albumin creatinin ratio 3.the relationship between the frequency of aortic plaques and the change of ABI value 4.comparison of aortic plaque findings between non-obstructive general angioscopy and aortic CT 5.the comparison between coronary and aortic plaque findings with non-obstructive general angioscopy 6.the progression of aortic plaques 7.the relationship between aortic plaque and influence factors 8.the relationship between aortic plaque and brain atrophy with MRI 9.the relationship between aortic plaque and atherosclerosis with brain MRI 10.the relationship between aortic plaque and dementia score 11.the relationship between aortic plaque and carotid duplex ultrasound findings 12.the relationship between aortic plaque and SPP score 13.the relationship between aortic plaque and sarcopenia score 14.the frequency of occurrence of complication with non-obstructive general angioscopy during and 48 hours after the procedure 15.the relationships aortic plaques and clinical events	—

Measure

Time frame

1.the relationship between the frequency of aortic plaques and the increase of cerebral infarction with MRI 2.the relationship between the frequency of aortic plaques and the increase of urinary albumin creatinin ratio 3.the relationship between the frequency of aortic plaques and the change of ABI value 4.comparison of aortic plaque findings between non-obstructive general angioscopy and aortic CT 5.the comparison between coronary and aortic plaque findings with non-obstructive general angioscopy 6.the progression of aortic plaques 7.the relationship between aortic plaque and influence factors 8.the relationship between aortic plaque and brain atrophy with MRI 9.the relationship between aortic plaque and atherosclerosis with brain MRI 10.the relationship between aortic plaque and dementia score 11.the relationship between aortic plaque and carotid duplex ultrasound findings 12.the relationship between aortic plaque and SPP score 13.the relationship between aortic plaque and sarcopenia score 14.the frequency of occurrence of complication with non-obstructive general angioscopy during and 48 hours after the procedure 15.the relationships aortic plaques and clinical events

—

Countries

Japan

Contacts

Public ContactAtsushi Hirayama

Nihon University School of Medicine, Division of Cardiology Division of Cardiology, Department of Medicine

atsushi-hirayama@oph.gr.jp03-3972-8111

Outcome results