Adult
Conditions
Interventions
enzyme-treated royal jelly Intake: 1,344 mg Ingestion: 84 day
Placebo Intake: 1,344 mg Ingestion: 84 day
Sponsors
Yamada Bee Company, Inc.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Target Healthy Japanese male and female subjects must satisfy the following selection criteria. - Aged betmeen 20 and 79 years. -With skin dryness. - Can understand and comply with the rules written in protocol during clinical study period. - With writteninformed consent spontaneously. - Judged appropriate for participation in this study by the doctor.
Exclusion criteria
Exclusion criteria: The following exclusion criteria apply to subjects. - Intake royal jelly or enzyme-treated royal jelly-containing food daily. - Have a food allergy or bee sting allergy or asthma. - Visit dermatology department(for the purpose of treating atopic dermatitis etc.). - With strange skin conditions at measurement points. - Intake medicines or health foods that may affect results. - Have a disorder to absorption, distribution, metabolism, excretion of food, such as digestive tract, liver, kidney, heart and cardiovascular system. - With a history of the surgery considerable in the gastrointestinal tract site, for example, gastrectomy, stomach and intestines suturation, intestinal tract resection and so on. - Undergoing medication treatment or going to receive medication. - Conducting hormone replacement therapy. - Have received a cosmetic medicine/ - Will get sunburned during the test period. - Can not continue regular life - Have an irregular habit because of working at night or working under work-shift form. - Have taken the blood sampling either 200 mL within 4 weeks or 400 ml within 3 months at the time of starting this clinical study. - Drinks more than 500 ml beer daily - A smoker. - Nursing or pregnant woman. - Participated in other clinical trial including patch test of cosmetics within last 3 months. - Working at the health food, cosmetics or pharmaceutical company. - Judged not appropriate by principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin moisture content | — |
Secondary
| Measure | Time frame |
|---|---|
| -Indexes for skin conditions (transepidermal water loss, skin viscoelasticity, visual evaluation, etc.). -Changes in Physical examinations from the baseline evaluation (visit0) (interview, auscultation, percussion, inspection, palpation, etc.) -Clinical laboratory values. | — |
Countries
Japan
Contacts
Public ContactNobuaki Okumura
Yamada Bee Company, Inc. Institute for Bee Products & Health Science R&D department
Outcome results
None listed