Patients with planning muscle biopsy
Conditions
Interventions
The group with single-dose antibiotic prophylaxis of cefazolin (1g) at muscle biopsy.
The group without antibiotic prophylaxis at muscle biopsy
Sponsors
Kumamoto university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Over 20 years old and less than 80 years old 2) Patient or proxy who can provide a informed consent
Exclusion criteria
Exclusion criteria: 1) Patients who are not hospitalized in neurology 2) Less than 20 years old patients 3) Over 80 years old patients 4) Patients who are pregnant or might be pregnant 5) Immunocompromised patients 6) Patients with anamnesis of diabetes 7) Patients with over body mass index (BMI) of 25 kg/m2 8) Patients with experience of allergia for Cephalosporin antibiotic 9) Patients with anamnesis of anaphylactic shock for Cephalosporin 10) Patients with experience of hypersensitivity for local anesthetic such as anilide 11) Patients with over serum creatinine level 1.5 mg/dl 12) Patients with an infectious disease 13) Patient with treatment plan of immunosuppressive therapy immediately after muscle biopsy 14) Patients who have skin lesion at muscle biopsy planed region 15) Patients who are judged inappropriate for this trial by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and proportion of wound infection after muscle biopsy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Background characteristics of patients 2) Adverse event of antibiotic 3) Wound score at the muscle biopsy performed region 4) characteristics of patients with wound infection 5) The relationship between days until the suture removal and the treatment with or without antibiotic 6) The relationship between body temperature and the treatment with or without antibiotic 7) The relationship between longitudinal changes of blood test (RBC, WBC, the subsets, PLT, Hb, BUN, Crea, TP, Alb, CK, AST, ALT, CRP) and the treatment with or without antibiotic 8) The relationship between longitudinal changes of blood test (RBC, WBC, the subsets, PLT, Hb, BUN, Crea, TP, Alb, CK, AST, ALT, CRP) and disease type, muscle biopsy performed region, operative duration of muscle biopsy and the value of manual muscle testing 9) The relationship between operative duration of muscle biopsy and disease type, muscle biopsy performed region, the value of manual muscle testing | — |
Countries
Japan
Contacts
Public ContactKoutaro Takamatsu
Graduate School of Medical Sciences, Kumamoto University Department of Neurology
Outcome results
None listed