The impact of laxatives on microbiome-related metabolites in patients with chronic heart failure

The impact of laxatives on microbiome-related metabolites in patients with chronic heart failure - Association between laxatives and gut microbial metabolites in heart failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034529

Enrollment

Registered

2018-10-16

Start date

2018-11-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Interventions

Oral inteke of usual dosage of laxatives once daily. 1 to 3-month intervention period.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Heart failure patients who were diagnosed by Framingham criteria and had constipation

Exclusion criteria

Exclusion criteria: Patients with renal failure, bowel diseases, or active infectious diseases

Design outcomes

Primary

Measure	Time frame
microbiome-related metabolites	—

Secondary

Measure	Time frame
gut microbiota	—

Countries

Japan

Contacts

Public ContactTomoya Yamashita

Kobe University Graduate School of Medicine Division of Cardiovascular Medicine, Department of Internal Medicine

tomoya@med.kobe-u.ac.jp078-382-5846

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026