Randomized controlled study on the efficacy of the exercise and amino acid for the elderly with esophageal squamous cell carcinoma during neoadjuvant chemotherapy.

Randomized controlled study on the efficacy of the exercise and amino acid for the elderly with esophageal squamous cell carcinoma during neoadjuvant chemotherapy. - Randomized controlled study on the efficacy of the exercise and amino acid for the elderly with esophageal squamous cell carcinoma during neoadjuvant chemotherapy.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034505

Enrollment

Registered

2018-10-16

Start date

2018-10-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

Taking exercise with Power Plate for 10 days of the every neoadjuvant chemotherapy course. Nutritional intervention by the amino acid intake after exercise. No exercise and no nutritional interventi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) the subjects aged 65 years or older with thoracic esophageal squamous cell carcinoma who will be intended to take surgery. 2) the subjects treated with neoadjuvant chemotherapy. 3) the subjects with written informed consent. 4) the subjects with the ability to intake amino acid (not necessarily oral intake, but also intake with feeding tube).

Exclusion criteria

Exclusion criteria: 1) the subjects with effort angina, chronic heart failure and tachyarrhythmia. 2) the subjects with chronic respiratory failure. 3) the subjects not able to walk by themselves (ECOG-PS>=3). 4) the subjects with chronic kidney disease. 5) the subjects with severe hepatic dysfunction. 6) the subjects not able to take exercise. 7) the subjects with uncontrolled multiple primary cancer. 8) the subjects judged by the investigator to be unfit to participate in the study

Design outcomes

Primary

Measure	Time frame
The change of skeletal muscle mass during neoadjuvant chemotherapy	—

Secondary

Measure	Time frame
The incidence of postoperative complications. The incidence of adverse events of chemotherapy. The change of CGA, body composition, body function, and QOL before chemotherapy, after chemotherapy, after surgery, and 1 year after surgery.	—

Countries

Japan

Contacts

Public ContactNorihiro Matsuura

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Department of Gastroenterological Surgery Graduate School of Medicine

nmatsuura11@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026