Prospective randomized single center study on sibling fertilized oocytes comparing a single step culture media system with antioxidants (Gx-TL) versus a one-drop sequential culture media system with antioxidants (Gx-1, Gx-ODS)

Prospective randomized single center study on sibling fertilized oocytes comparing a single step culture media system with antioxidants (Gx-TL) versus a one-drop sequential culture media system with antioxidants (Gx-1, Gx-ODS) - Culture in single step media versus one drop sequential culture media

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034495

Enrollment

128

Registered

2018-10-17

Start date

2018-10-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

One-drop sequential culture media system single step culture media system

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women coming for fertility treatment presenting with more than 6 normally fertilized oocytes at the time of fertilization assessment except for the exclusion criteria listed below. Having signed the study-specific consent form at the time of oocyte retrieval.

Exclusion criteria

Exclusion criteria: Surgically retrieved sperm cells. more than 30 normally fertilized oocytes. Normal fertilization rate less than 40 percent. Less than 6 fertilized oocytes on day 1. Split IVF.

Design outcomes

Primary

Measure	Time frame
The primary endpoint of the investigation is blastocyst formation on day 5 per allocated normally fertilized oocyte.	—

Secondary

Measure	Time frame
Secondary endpoints are: - Embryo development day 3 - Embryo quality day 3 - Embryo development day 5 - Embryo quality day 5 - Embryo development day 6 - Embryo quality day 6 - Total blastocyst formation (day 5 and day 6) - Utilization rate (embryos available for replacement and cryopreservation) - Clinical pregnancy rate - Implantation rate	—

Countries

Japan

Contacts

Public ContactNobuya Aono

Kyono ART Clinic Labolatory

aono@ivf-kyono.or.jp022-722-5991

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026