Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy

Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy - Investigation on exhaled nitrogen chemicals in lung cancer patients undergoing lobectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000034488

Enrollment

Registered

2018-10-15

Start date

2018-10-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lobectomy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients over 20 years at the time of obtaining informed consent 2) patients with lung cancer up to stage II 3) patients scheduled for lobectomy 4) patients with ASA PS 1 to 2

Exclusion criteria

Exclusion criteria: 1) patients undergoing surgery requiring general anesthesia within 3 months prior to obtaining informed consent 2) patients with heart disease 3) patients with arrhythmia 4) patients with poor control hypertenson 5) patients with respiratory dysfunction 6) patients with lung disease 7) patients with smoking history within 3 months before consent acquisition 8) patients with pulmonary hypertension 9) diabetic patients with poor control 10) patients with cerebrovascular disorders 11) patients with severe liver disease 12) patients with severe kidney disease 13) patients with declining blood clotting ability 14) patients with thrombocytopenia 15) patients who receive chemotherapy, radiation therapy, immunotherapy within 3 months prior to obtaining informed consent 16) patients with systemically or locally active infections 17) highly obese patients 18) women who may be pregnant or have a possibility of pregnancy 19) patients who received study drugs or investigational drugs within 3 months prior to obtaining informed consent 20) patinets whom research investigator has determined to be inappropriate

Design outcomes

Primary

Measure	Time frame
change in exhaled NO, NO2, HONO concentration during perioperative period	—

Secondary

Measure	Time frame
1) relevance of exhaled NO, NO2, HONO and collapsed lung and non-collapsed lungs during perioperative period 2) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period 3) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period 4) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period 5) relevance of exhaled NO, NO2, HONO and duration of collapse pulmonary during perioperative period	—

Measure

Time frame

1) relevance of exhaled NO, NO2, HONO and collapsed lung and non-collapsed lungs during perioperative period 2) relevance of exhaled NO, NO2, HONO and blood ROS during perioperative period 3) relevance of exhaled NO, NO2, HONO and blood cytokines during perioperative period 4) relevance of exhaled NO, NO2, HONO and pulmonary function during perioperative period 5) relevance of exhaled NO, NO2, HONO and duration of collapse pulmonary during perioperative period

—

Countries

Japan

Contacts

Public ContactKazumi Funaki

Tottori University Division of Anesthesiology and Critical Care Medicine

funapon1116@gmail.com0859-38-6657

Outcome results