Comparison of voglibose and pioglitazone in basal insulin with multiple oral hypoglycemic agents therapy using continuous glucose monitoring

Comparison of voglibose and pioglitazone in basal insulin with multiple oral hypoglycemic agents therapy using continuous glucose monitoring - Comparison of voglibose and pioglitazone in basal insulin with multiple oral hypoglycemic agents therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034426

Enrollment

Registered

2018-10-09

Start date

2018-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

40 outpatients with type 2 diabetes treated with metformin 1000mg, vildagliptin 100mg, tofoglifrozin 20mg, and glargine 300 for 3 month or longer are randomly allocated into 2 groups. Group 1: Voglib

next, glargine 300 injected at 8 am are titrated with an algorithm for 2 weeks

the dose of glargine 300 is then maintained for 2 week and fasting glcose levels are stabilized. (final registration criteria) 1 month after voglibose or pioglitazone are added, during hospitalizatio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: type 2 diabetes treated with metformin 1000mg, vildagliptin 100mg, tofoglifrozin 20mg, and insulin glargine 300 U/ml for 3 month or longer

Exclusion criteria

Exclusion criteria: patients who cannot achive the final registration criteria. severe renal dysfunction (eGFR less than 45) judged to be unsuitable for participation for medical reasons

Design outcomes

Primary

Measure	Time frame
24-h Percentage of time in target range (70~180 mg/dL)	—

Secondary

Measure	Time frame
24-h Mean absolute glucose (MAG) 24-h Glycemic variability percentage (GVP) Mean glucose level (24:00, 0:00-6:00, 8:00-24:00) Standard deviation (SD) (24:00, 0:00-6:00, 8:00-24:00) Coefficient of variation (CV) (24:00, 0:00-6:00, 8:00-24:00) High blood glucose index (HBGI) low blood glucose index (LBGI) Percentage of time in range (<70 mg/dL)	—

Countries

Japan

Contacts

Public ContactSoichi Takeishi

Inuyama Chuo General Hospital Diabetes

souichi19811225@yahoo.co.jp0568-62-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026