Severe trauma
Conditions
Interventions
Target hemoglobin level of red cell concentrate transfusion is defined as 7-9 g/dL.
Target hemoglobin level of red cell concentrate transfusion is defined as 10-12 g/dL.
Sponsors
Tohoku University Hospital Department of Emergency and Critical Care Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with severe traumas who were judged by an attending physician to have severe bleeding that induced unstable hemodynamics or the possibility thereof. OR Patients with severe traumas who were judged by an attending physician to present a possibility that severe bleeding could occur as a result of acute surgical treatments.
Exclusion criteria
Exclusion criteria: 1. Patients with cardiac arrest before or on arrival at the hospital 2. Patients transferred from other hospital 3. Patients who were determined to discontinue the aggressive treatment during the initial evaluation 4. Patients with a total burn surface area >=15% 5. Patients with pregnancy 6. Patients with chronic anemia (hemoglobin <=7 mg/dL) 7. Patients who refused any blood transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate [time frame: first 28 days after emergency department admission]. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Survival during the first 28 days after emergency department admission [time frame: first 28 days after emergency department admission]. 2. In-hospital mortality rate 3. Amount of blood products (red cell concentration, platelet concentrate, and fresh frozen plasma) on one, seven, and 28 days [time frame: first 1 day after emergency department admission; first 7 days after emergency department admission; and first 28 days after emergency department admission]. 4. Event-free days during 28 days [time frame: first 28 days after emergency department admission]. Ventilator-free days Catecholamine-free days ICU-free days 5. Rates of organ dysfunction [time frame: first 7 days after emergency department admission]. Renal dysfunction Respiratory dysfunction Liver dysfunction 6. Complications while in the hospital [time frame: until discharge of the first 28 days after emergency department admission] Deep venous thrombosis Pulmonary embolism Acute myocardial infarction Gastrointestinal ischemia Transfusion-related acute lung injury Sepsis 7. Glasgow outcome scale at discharge | — |
Countries
Japan
Contacts
Public ContactMineji Hayakawa
Hokkaido University Hospital Department of emergency medicine
Outcome results
None listed