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Circulating Tumor DNA Sequencing Study for Rare Cancers: an Ancillary Research Study to the MASTER KEY Registry Study (NCCH1612)

Circulating Tumor DNA Sequencing Study for Rare Cancers: an Ancillary Research Study to the MASTER KEY Registry Study (NCCH1612) - Circulating Tumor DNA Sequencing Study for Rare Cancers

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000034394
Enrollment
100
Registered
2018-10-22
Start date
2018-11-05
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rare cancers, Rare hisotogical subtypes of major cancers, Carcinoma of unknown primary

Interventions

None listed

Sponsors

National Cancer Center Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients aged 16 years or older at registration. 2) Patients who meet the eligible criteria for the MASTER KEY Registry study (NCCH1612) and have provided a written consent to the MASTER KEY Registry study (NCCH1612). (Enrollment into the MASTER KEY Registry study (NCCH1612) must be done before enrollment into this research study. 3) Patients who provided a written consent to participate in the study (for patients less than 20 years of age, their legally acceptable representative must give consent). For patients who have a will to consent but are physically unable to provide a signature, an allograph by a relative is applicable.

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

MeasureTime frame
1) Overall incidence of any genetic alterations(analyzed in all rare cancer patients cohort and in each histopathlological subgroup cohort) 2) Incidence of individual genetic alteration(analyzed in all rare cancer patients cohort and in each histopathlological subgroup cohort)

Secondary

MeasureTime frame
To investigate the congruence of the reported gene alterations from this research study and tissue-based NGS from prior tests, treatment patterns according to each gene alteration, response to treatment, etc.

Countries

Japan

Contacts

Public ContactHitomi Okuma

National Cancer Center Hospital Clinical Trial Management Section, Research Management Division/Department of Breast and Medical Onc

hsumiyos@ncc.go.jp03-3542-2511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026