Randomized controlled trial of endovascular therapy for acute large vessel occlusion with large ischemic core

Randomized controlled trial of endovascular therapy for acute large vessel occlusion with large ischemic core - RESCUE-Japan LIMIT

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034388

Enrollment

200

Registered

2019-03-31

Start date

2018-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute large vessel occlusion

Interventions

Best medical treatment for cerebral infarction Best medical treatment for cerebral infarction with endovascular treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Acute cerebral infarction patient 2) Patients's age => 18 3) Patients with NIHSS => 6 4) Prestroke Modified Rankin Score 0-1 5) ICA or M1 Occlusion on CT angiography or MR angiography 6) ASPECTS 3-5 or DWI-ASPECTS 3-5 7) Randamization can be finished within 6 hours from last known well time, or 6 to 24 hours from last well known well time without positive lesion on MRI-FLAIR image. 8) Endovascular treatment can be initiatedwithin 60 minutes from randomization 9) Patient or Legally Authorized Representative has signed the Informed Consent form

Exclusion criteria

Exclusion criteria: 1) Significant mass effect with midline shift 2) Known allergy to contrast agents 3) Evidence of acute intracranial hemorrhage 4) Pregnant 5) Clinical evidence of chronic occlusion 6) High risk of hemorrhage (platelet < 40,000/ul, APTT > 50 second or PT-INR > 3.0) 7) Participating in any other therapeutic investigational trial 8) Subjects who, in the judgment of the investigator, are likely to be non-compliant or uncooperative during the study

Design outcomes

Primary

Measure	Time frame
modified Rankin Scale 0-3 at 90 days	—

Secondary

Measure	Time frame
1) modified Rankin Scale 0-2 at 90 days 2) modified Rankin Scale 0-1 at 90 days 3) Distribution of patients across the ordinal modified Rankin scale 4) NIHSS improvement 8 points or more at 48 hours Safety outcome 1) Symptomatic intracranial hemorrhage within 48 hours 2) Intracranial hemorrhage within 48 hours 3) Death 4) Recurrence of cerebral infarction within 90 days 5) Decompressive craniectomy within 7 days	—

Measure

Time frame

1) modified Rankin Scale 0-2 at 90 days 2) modified Rankin Scale 0-1 at 90 days 3) Distribution of patients across the ordinal modified Rankin scale 4) NIHSS improvement 8 points or more at 48 hours Safety outcome 1) Symptomatic intracranial hemorrhage within 48 hours 2) Intracranial hemorrhage within 48 hours 3) Death 4) Recurrence of cerebral infarction within 90 days 5) Decompressive craniectomy within 7 days

—

Countries

Japan

Contacts

Public ContactKazutaka Uchida

Hyogo College of Medicine Department of Neurosurgery

rescue-j@hyo-med.ac.jp0798-45-6458

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026