Cultivated oral mucosal epithelial transplantation in severe ocular surface diseases, phase-3 study

Cultivated oral mucosal epithelial transplantation in severe ocular surface diseases, phase-3 study - Cultivated oral mucosal epithelial transplantation, phase-3 study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034335

Enrollment

Registered

2018-10-01

Start date

2018-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe ocular surface diseases

Interventions

Confirmation for efficacy and safety of cultivated oral mucosal epithelial transplantation as mucosal epithelial supply treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: severe ocular surface diseases with advanced adhesion score another eye tissue is unavailable adhesion score is more than 4 stable condition within 4W

Exclusion criteria

Exclusion criteria: corneal infection or uncontrolable glaucoma in the target eye Difficulty with the collection of oral mucosal epithelia drug or xenogeneic protein hypersensitivity uncontrolable diabetes infection with virus or syphilis pregnant pretreated for the target eye, or under another trial difficulty with keeping trial procedures

Design outcomes

Primary

Measure	Time frame
The change of adhesion score decided by an independent committee (24W)	—

Countries

Japan

Contacts

Public ContactKojiro Imai

Kyoto Prefectural University of Medicine Department for Medical Innovation and Translational Medical Science

kpum_comet-office@umin.ac.jp075-251-5308

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026