Association of coronary plaque morphology with impairment of cholesterol uptake capacity (CUC), a novel indicator for high-density lipoprotein (HDL) functionality: OCT-based Observation Study

Association of coronary plaque morphology with impairment of cholesterol uptake capacity (CUC), a novel indicator for high-density lipoprotein (HDL) functionality: OCT-based Observation Study - Association of coronary plaque morphology with cholesterol uptake capacity (CUC), a novel indicator for HDL functionality

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000034324

Enrollment

150

Registered

2018-09-29

Start date

2010-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with dyslipidemia and with or suspected of having coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Retrospective observational study. Patients who was undergone coronary angiography and measured CUC after January 2010 in Kobe university hospital.

Exclusion criteria

Exclusion criteria: 1) anatomically unsuitable target artery for OCT 2) patients who have had heart failure (NYHA >III) 3) renal insufficiency with baseline creatinine level > 2.0 mg/dL except for those under hemodialysis 4) who had a history of cancer in the previous 5 years 5) who were under inflammatory conditions such as active infections, inflammatory arthritis, or connective tissue disease.

Design outcomes

Primary

Measure	Time frame
1.Coronary plaque characteristics assessed by the optical coherence tomography (OCT). 2.Association between coronary plaque morphology assessed by OCT and cholesterol uptake capacity.	—

Secondary

Measure	Time frame
Association between coronary plaque characteristics assessed by the intravascular ultrasound(IVUS) or coronary angiography and cholesterol uptake capacity.	—

Countries

Japan

Contacts

Public ContactRyuji Toh

Kobe university graduate school of medicine Evidence-based laboratory medicine

rtoh@med.kobe-u.ac.jp078-382-5846

Outcome results