Acute pancreatitis
Conditions
Interventions
Start low-fat solid food immediately (within 48 hours from diagnosis even if it is late) while allowing the use of an analgesics.
Gradually increase the amount of fat of diet after fasting with no fo
not solid, fat
less than 5 g per day Step 3:Form
any form, fat
5 g or more and less than 15 g per day Step 4:Form
solid, fat
15 or more - 35 or less g per day
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who diagnosed with acute pancreatitis Requires 2 of the following three features 1.upper abdominal pain of acute onset often radiating through to the back 2.serum amylase or lipase activity greater than three times the upper limit of normal 3.findings on cross-sectional abdominal imaging consistent with acute pancreatitis. The patients who had less than 2 points by Modified Marshall scoring system Respiratory: PaO2/FiO2>=301 Renal: Creatinine<=1.8mg/dl Cardiovascular: systolic blood pressure>=90mmHg or systolic blood pressure>=90mmHg with fluid responsive
Exclusion criteria
Exclusion criteria: 1)Patients with pancreatitis caused by obstruction of the pancreatic duct and have not been resolved the obstruction 2)Patients who have a complication of cholangitis 3)Traumatic pancreatitis 4)Patients who are not able to eat solid food due to the reduction of swallowing function 5)Patients who are not able to eat solid food due to consciousness disturbance 6)Patients who can not expect sufficient dietary intake 7)Patients with paralytic ileus by CT or ultrasound 8)Patients who regularly take medicine for pain with chronic pancreatitis 9)Patient judged inappropriate for this study by the attending physician 10)Patients who are older than 1 week after the onset of pancreatitis 11) Patients who do not agree with this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage diagnosed with moderately severe or severe by the revised Atlanta classification with day 4. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage diagnosed with severe by the revised Atlanta classification with day 4. Percentage diagnosed with moderately severe or severe by the revised Atlanta classification during admission(within two weeks). Percentage diagnosed with severe by the revised Atlanta classification during admission(within two weeks). Percentage diagnosed as severe using the prognostic factor according to the severity criteria of the Ministry of Health, Labor and Welfare with day 4. In-hospital mortality In-hospital mortality due to pancreatitis Number of days until disappearance of abdominal pain Abdominal pain relapse rate Number of days from diagnosis of pancreatitis to healing length of hospital stay The changes in CRP and Ca level(from day 0 to day 2 and from day 0 to day 4) Cost Hospitalization rate due to recurrence of pancreatitis within 4 weeks after discharge | — |
Countries
Japan
Contacts
Public ContactMasayasu Horibe
Keio University School of Medicine Division of Gastroenterology and Hepatology, Department of Internal Medicine
Outcome results
None listed