Effect of GUM-CHEWING before meal on postprandial plasma glucose, Secretion of Insulin, Glucagon and gastrointestinal Hormones, healthy volunteer Trial

Effect of GUM-CHEWING before meal on postprandial plasma glucose, Secretion of Insulin, Glucagon and gastrointestinal Hormones, healthy volunteer Trial - Effect of GUM-CHEWING before meal on postprandial plasma glucose, Secretion of Insulin, Glucagon and gastrointestinal Hormones, healthy volunteer Trial (GUM-CHEWING SIGHT study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000034185

Enrollment

Registered

2018-09-18

Start date

2018-09-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteer

Interventions

Study subjects will perform different meal load tests over 3 days. Each meal load test will be conducted with at least 1 week interval. &lt

No gum before meal&gt

Study subjects take test meal 1 in test meal load. Study subjects engulf each 1/12 of the test meal 1 after chewing it 30 times. Study subjects continue the above 12 times to complete the test meal

Sato-No-Gohan&quot

(polished rice, 200 g), including energy 294 kcal, protein 4.2 g, lipid 0 g, carbohydrate 67.8 g, and sodium 0 mg (manufactured by Sato Foods Co., Ltd.) &lt

Gum-chewing before meal&gt

Study subjects take test meal 1 after chewing test meal 2 in test meal load. Study subjects chew test meal 2 15 min at a speed of 80 times/min. Study subjects eat the test meal 1 as a same method wi

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Subjects who meet all of the following criteria are included in this study. 1. healthy volunteers without glucose metabolism disorder 2. subjects with normal dental occlusion without any structural or functional disorder in stomatognathic system 3. subjects who does not receive any pharmacological treatments 4. males who are aged of 30 years or older and younger than 50 years when giving their consent 5. subjects who provide written consent form to participate in this study after full explanation of the study

Exclusion criteria

Exclusion criteria: Subjects who fall into any of the following criteria are excluded from participating in the study. 1. subjects with dementia or psychiatric disorder, or those who need legal representatives for providing their consent 2. subjects with alcoholics 3. subjects with hearing disorder 4. subjects with other conditions that the investigator/researcher thinks inappropriate for the study

Design outcomes

Primary

Measure	Time frame
Differences of changes in plasma glucose, insulin, glucagon, and gastrointestinal hormones (ghrelin and GLP-1) from before meal to after meal.	—

Secondary

Measure	Time frame
Differences of changes in subjective evaluation scores in study subjects' hunger, fullness, desire to eat, and preoccupation measured by visual analog scale with food from before meal to after meal.	—

Countries

Japan

Contacts

Public ContactHiroki Takayama

Soiken Inc. Clinical Study Support Division

takayama@soiken.com03-3295-1350

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026