None (Healthy adults)
Conditions
Interventions
Microorganism containing food (capsule form), once a day for 8 weeks
Microorganism not containing food (capsule form), once a day for 8 weeks
Sponsors
TES holdings Co., Ltd.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1)Healthy Japanese females aged from 20 to less than 45 years old, when giving the informed consent. 2)Healthy individuals not having any chronic disease. 3)Individuals whose skin bacteria can be detected from forehead. 4)Individuals who generally have skin problems. 5)Individuals who are working more than 3 days per week. 6)Individuals who give the informed consents in writing, after receiving enough explanation of the purpose and details of the study, understanding the study well, and deciding to attend the study with their own will. 7)Individuals who can accomplish their tasks in the study at the appointed date. 8)Individuals who are judged suitable for this study by the investigators.
Exclusion criteria
Exclusion criteria: 1)Individuals who have diseases with medications. 2)Individuals who receive medications within 1 month before examination. 3)Individuals who have a medical history of serious disease of liver, kidney, heart, lung, blood and digestive tract. 4)Individuals who have severe skin disorder, such as skin burn. 5)Individuals who are difficult to take samples for gene expression analysis. 6)Individuals who refuse to disclose their biological sexes. 7)Individuals who may have an allergic symptom to test foods, or individuals who may have a serious allergic symptom to other foods, or medicaments. 8)Individuals who are alcoholic or have mental disorders. 9)Individuals who have a smoking habitat. 10)Individuals who will change their life style during test period, such as traveling for a long period. 11)Individuals who cannot keep from direct sunlight exposure, such as tanning activities, during test period. 12)Individuals who may occur seasonal allergic symptoms, such as hay fever, and receive medications during test period. 13)Individuals who have severe menopausal symptoms. 14)Individuals who are taking or took foods or medications, specified for skin conditions or are planning to take these foods during test period. 15)Individuals who cannot stop eating foods related with this test foods during test period. 16)Individuals who have severe anemia. 17)Individuals who donate more than 200 ml of blood within 1 month or more than 400 ml of blood within 3 months. 18)Individuals who have a surgical or treatment history on the regions of measurement within 6 months. 19)Individuals who are pregnant, breastfeeding, or planning to be pregnant in the near future. 20)Individuals who are participating or participated in another clinical trial within the last 3 months. 21)Individuals who and whose family living with them work for a company manufacturing or selling healthy foods or cosmetics. 22)Individuals who are judged as unsuitable for participating this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Analysis of skin microbiome - Analysis of expression level of skin-condition-related genes | — |
Secondary
| Measure | Time frame |
|---|---|
| - Evaluation of skin condition by medical doctor - Skin color difference (LAB value) - Trans-epidermal water loss - Skin moisture content - VISIA skin analysis - Questionnaires | — |
Countries
Japan
Contacts
Public ContactToshiyasu amura
TES holdings Co., Ltd. Division of Clinical Research Business
Outcome results
None listed