Growth promotion effect of bifidobacteria
Conditions
Interventions
Both groups are administered from hospitalization until discharge. <
Intervention>
1 packege of Bifidobacterium breve and 0.3 g of crystalline kestose powder and 1.125 ml of water for injection, and then administer 1 ml thereof once a day (the number of bacteria is 500 million).
Bot
Control>
1 packege of Bifidobacterium breve and lactulose (Refolos syrup) 0.3 ml and 1 ml water for injection are mixed, 1 ml of which is administered once a day (the number of bacteria is 500 million).
Sponsors
Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Less than 2,000g of low birth weight infants who were admitted to NICU and GCU.
Exclusion criteria
Exclusion criteria: 1) Neonate whose birth weight 2000g or more. 2) Infants with surgical diseases (esophageal atresia, diaphragmatic hernia, etc.), with low possibility of long-term enteral nutrition 3) Neonates judged to be ineligible by research facility director or research doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of bifidobacteria in stool specimens collected at 1, 2, 4 weeks after birth in each group | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.16S gut microbiome analysis at 1, 2, 4 weeks after birth in each group 2.Measurement of short-chain fatty acids in stool specimens collected at 1, 2, 4 weeks after birth in each group 3.Frequency of defecation (days 0, 7, 14, 21, 28) 4.Difference in time until birth weight restoration in each group. 5.Weight gain rate upto corrected 40th week of gestational age in each group | — |
Countries
Japan
Contacts
Public ContactSaori Tanaka
Chiba University Hospital Department of Pediatrics
Outcome results
None listed