Syphilis
Conditions
Interventions
amoxycillin 500 mg orally three times a day 14 days for early syphilis(primary, secondary and early latent syphilis) 28 days for late syphilis(late latent syphilis and unknown duration of syphil
Sponsors
self-finance
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) HIV patient 2) The diagnosis of syphilis was based on a) or b) a) Serum rapid plasma regain(RPR) titers is 8 or greater and positive Treponema. Pallidum Hemagglutination(TPHA) result. When serum RPR titers is 8, the diagnosis of syphilis requires signs of syphilis like chancre or skin rash. b) 4-fold or more rise in RPR titer from the individual's prior test
Exclusion criteria
Exclusion criteria: 1) pregnant or breast feeding woman 2) a history of amoxycillin or probenecid allergy 3) otosyphilis, ocular syphilis or neurosyphilis diagnosed based on the findings of cerebrospinal fluid 4) patient who needs antibiotics other than the antibiotics we used in this study which is effective for syphilis at diagnosis 5)patient who started antibiotics within 3 weeks before diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate at one year after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment success rate at 3, 6, 9 months after treatment and adverse event rate | — |
Countries
Japan
Contacts
Public ContactNaokatsu Ando
National Center for Global Health and Medicine Hospital AIDS Clinical Center
Outcome results
None listed