Identification of novel biomarkers for screening, diagnosis, and prediction of renal prognosis in kidney diseases - Multicenter prospective study - (INSPIRE study)

Identification of novel biomarkers for screening, diagnosis, and prediction of renal prognosis in kidney diseases - Multicenter prospective study - (INSPIRE study) - INSPIRE Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033983

Enrollment

6000

Registered

2019-01-01

Start date

2019-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: I. Screening Patients with kidney diseases Patients with urinary abnormality or impaired renal function at 16 institutions (Okayama university hospital, Okayama Okayama Saiseikai General Hospital, National Hospital Organization Okayama Medical Center, Kurashiki Central Hospital, Japanese Red Cross Okayama Hospital, Japanese Red Cross Society Himeji Hospital, Cugoku Central Hospital, Hiroshima City Hiroshima Citizens Hospital, Onomichi Municipal Hospital, Kousei General Hospital, Ehime Prefectural Central Hospital, Matsuyama Shimin Hospital, Mitoyo General Hospital, Kagawa Prefectural Central Hospital, Kagawa Rosai Hospital, and Kochi Health Sciences Center) between January 2019 and December 2028 will be included. Impaired renal function is based on the decision of each primary physician. Estimated glomerular filtration rate [eGFR]< 60 ml/min/1.73m2 is generally included in the criteria, while other parameters such as eGFR decline and relative low levels of eGFR based on age and physical build, can be included the principal. II. Healthy volunteers 1. Donors of kidney transplantation in our hospital since January 1, 2019 2. Donors without urine abnormalities such as hematuria and proteinuria. 3. Donors who are not diagnosed with any kidney disease in the results of 0 hour-renal biopsy. 4. Donors who agree to keep their blood and urine sample in OKADAI BIOBANK (Biobank of Okayama university hospital).

Exclusion criteria

Exclusion criteria: People who decline the entry of this study.

Design outcomes

Primary

Measure	Time frame
Differentiating IgA nephropathy from other renal diseases by using various biomarkers including urinary glycan profiling	—

Countries

Japan

Contacts

Public ContactKoki Mise

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Nephrology, Rheumatology, Endocrinology and Metabolism

kokims-frz@okayama-u.ac.jp086-235-7235

Outcome results