None listed
Conditions
Interventions
Consume testfood-1, one package a day for 10 weeks. Conduct health check, QOL questionnaire and stool analysis at 0, 4 and 8 weeks, skin tests at 4 and 8 weeks, blood tests at 8 weeks after start of t
Sponsors
CPCC Company Limited
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Females aged 30 to 49 years old. (2)Subjects who are before menopause and have stable menstrual period within 28 days to 35 days. (3) Subjects who are aware to bad condition of their skin. (4) Subjects who show understanding of the study procedures and agreement with participating the study by written informed consent prior to the study.
Exclusion criteria
Exclusion criteria: Subjects who (1)consume yogurt over 3 days a week. (2)consume lactic acid bacteria beverages and/or bifidobacterium beverages over 3 days a week. (3)consume health food which have intestinal action. (4)consume supplements include lactic bacteria, bifidobacterium and/or yeast over 3 days a week. (5)consume vitamin supplements over 3 days a week. (6)regularly use gastrointestinal agonist and/or female hormone. (7)repeat constipation and diarrhea. (8)defecate under 2 times in a week. (9)defecate over 10 times in a week. (10)have taken antibiotics within a month (11)are being treated uterine and/or that medical historie. (12)are pregnant or are lactating. (13)have allergy to medicine and/or food. (14)are atopic dermatitis, contact dermatitis and/or skin hypersensitivity. (15)Subjects who have birthmark, scar and/or acne on the part of measurement. (16)have severe past and/or current medical history in heart, liver, kidney and/or digestive organs. (17)are heavy drinkers of alcohol. (18)have excess irregular life rhythm such as shift work or midnight work. (19)are currently being treated or who plan to be treated for pollen allergy. (20)have rough skin because of pollen allergy. (21)have excess suntan and/or who stay outside long time. (22)are receiving special care of face and/or arm in the service. (23)plan to go traveling abroad and/or to go swimming in the sea during this test period. (24)are participating, have participated within 4 weeks and/or who plan to participate after informed consent of this test, in clinical test of other medicine or health food. (25)donated over 200mL blood and/or blood components within a month. (26)donated over 400mL blood within the last 4 months. (27)will be collected over 800mL blood and/or blood components when the sampling amounts within the last 12 months are adding to the planned sampling amounts of this study. (28)Others they have been determined ineligible by principal investigator or sub-investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| *Moisture content of the horny layer *Viscoelasticity of the skin *Amount of water transpiration from the surface of the skin *VISIA's indicators(spots, wrinkles, texture, pores, UV spots, brown spots, red areas, porphyrins) | — |
Secondary
| Measure | Time frame |
|---|---|
| *Oil content of the skin *Defecation frequency *Days of defecation *Fecal properties *Feelings in defecation *Microbiota of gut *Short chain fatty acids of feces *Fecal spoilage products *Moisture of feces *pH of feces *Ammonia of feces * QOL questionnaire *The Japanese Version of the Constipation Assessment Scale MT version (CAS-MT) *Simplified Menopausal Index (SMI) *Body weight, Body fat percentage, BMI *Blood test *Urine test * Incidence of adverse events and of side effects | — |
Countries
Japan
Contacts
Public ContactMasanori Numa
CPCC Company Limited Planning & Sales Department
Outcome results
None listed