NERD(Grade M by revised LA classification)
Conditions
Interventions
On-demand therapy using 20-mg vonoprazan (8 weeks)
Sponsors
Nippon Medical School Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 20 years old and younger than 80 years old 2. Both males and females 3. Outpatients 4. Patients who have been diagnosed with NERD (LA classification, Grade M), maintain remission by standard-dose PPI therapy, and satisfied with the treatment, and have an esophageal hiatal hernia smaller than 2cm 5. Patients who understood study, and provided written consent based on their own will
Exclusion criteria
Exclusion criteria: 1. Allergy patients to drugs being studied 2. Patients with critical dysfunction of liver and kidney 3. Patients with malignancy 4.Patints suspected with active infection 5. Pregnant or possibility of being pregnant, and those who are breastfeeding 6. Study participation decided to be contraindicated by the parson in charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The overall satisfaction level after 8-week on-demand therapy 2. The gastrin level before breakfast and the number of 20-mg vonoprazan tablets taken before and after on-demand therapy (8 weeks) | — |
Countries
Japan
Contacts
Public ContactKatsuhiko Iwakiri
Nippon Medical School Department of Gastroenterology
Outcome results
None listed